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Polymorphisms in DNA repair and multidrug resistance genes among Sindhis of Central India(Environmental Toxicology and Pharmacology)
(Pramanik S, Surendran ST, Arumugam S, Devi S, Krishnamurthi K, Chakrabarti T (Corresponding Author),40(2),,480-485,Year : 2015)
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Polymorphisms in DNA repair and multidrug resistance genes might contribute to interindividual and interethnic differences in DNA repair capacity and drug disposition respectively. In the present study, we determined the allele and genotype frequencies of four single nucleotide polymorphisms (SNPs) located in the DNA repair genes, XRCC1, XRCC3, XPD, OGG1, namely XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, and OGG1 Ser326Cys, respectively and two SNPs located in the multidrug resistance gene, ABCB1, namely ABCB1 C3435T and ABCB1 C1236T, in 33-35 healthy and unrelated Sindhi individuals, residing in the Vidarbha region of Central India and compared them with the Maharashtrian population from the same geographical region and some other HapMap populations from the HapMap database. The study findings reveal that the Indian Sindhis are closely related to the Maharashtrians as well as Utah residents with Northern and Western European ancestry and Gujarati Indians in Houston, Texas in the HapMap database.
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Effects of unregulated anthropogenic activities on mixing ratios of volatile organic air pollutants?A case study(Journal of the Air & Waste Management Association)
(D Majumdar, PS Rao, B Dinda Chakraborty, A Srivastava. ,65(9),,1094-1103,Year : 2015)
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"During the months of October to November, many important festivals are celebrated in India. Celebration of these festivals are marked by extensive use of fireworks or pyrotechnics, bonfire, incense burning, open air community cooking, and temporary eateries using crude fuel such as coal, wood, kerosene, cow dung, burning of raw/semiwood, and coconut shells. The present study deals with the influence of these unregulated anthropogenic activities on ambient mixing level of volatile organic compounds (VOCs), especially some carbonyl compounds. The study was undertaken in the metropolitan city of Kolkata, India, with very high population density, which is even higher during festival period. The average total carbonyl level at different sites in Kolkata varied from 134.8 to 516.5 μg m−3 in pre-festival season, whereas in post-festival season the same varied from 252.2 to 589.3 μg m−3. Formaldehyde to acetaldehyde ratio altered from 0.62 in pre-festival season to 1.78 in post-festival season. Diurnal variation also altered, indicating variation in source composition of carbonyls. The total ozone forming potential calculated for all 14 carbonyls in pre-festival season increased by 35% in post-festival season. The effect of anthropogenic activities typical to the event of Diwali night characterized by intense execution of pyrotechnics resulted in significantly high level of carbonyl VOCs. Principal component analysis study for the event of Diwali shows clear contribution of the event on certain carbonyl VOCs. The results indicate elevated primary emissions of these pollutants and also their effect on formation of secondary pollutants. The study emphasizes the need of generating awareness among the communities in society as well as need for regulations to minimize the emissions and related hazards to the extent possible"
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Frequency and genotype distribution of ABCB1 gene polymorphisms among Maharashtrian population of Central India(Xenobiotica)
(Pramanik S, Surendran ST, Devi S, Krishnamurthi K, Chakrabarti T Corresponding Author,446,,579-582,Year : 2014)
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- Apart from conferring multidrug resistance to cancer cells, P-glycoprotein (P-gp) encoded by the gene ABCB1 (also, known as Multidrug resistance gene, MDR1), plays a major role in drug disposition. Single nucleotide polymorphisms (SNPs) in the ABCB1 gene might contribute to inter-individual and ethnic differences in drug disposition and thereby, could influence the outcome and prognosis of certain diseases.
- India is one of the most ethnically and genetically diverse regions of the world. This study was undertaken with a view to determine the allele and genotype frequencies of C3435T and C1236T polymorphisms in the ABCB1 gene among the Maharashtrian population, residing in the Vidarbha region of central India and compare them with HapMap and other Indian populations. The common synonymous C3435T polymorphism has been found to be associated with lower P-gp functional expression and drug uptake, alone or in conjunction with a few other linked SNPs like C1236T.
- The genotypes of C3435T and C1236T SNPs were determined by PCR-RFLP in 222 healthy and unrelated Maharashtrian individuals.
- According to the findings of this study, the Maharashtrians were found to be not significantly different from the Gujarati Indians in Houston, Texas in the HapMap database.
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Prevalence of formaldehyde in indoor air of gross anatomy laboratory and cadaver storage room of a medical college(Journal of Environmental and Occupational Science)
(Shailesh Gahukar, Ujwala Ramteke, Deepanjan Majumdar,
Raman Malviya, Dinkar Patil, Jitendra Trivedi, Chalapati Rao,
Ashok H. Kale,,,181-185,Year : 2014)
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Concentration of formaldehyde (FA) which is used to preserve cadavers for dissection in medical colleges was monitored in indoor air including at the breathing level in dissection classes during a 2-week study in a gross anatomy laboratory and also in the cadaver storage room in a Medical College in India in 2012. Materials and Air samples were collected for 30 min and 3 h to commensurate with World Health Organization (WHO) standard (short-term exposure limit) value of FA (30-min) and dissection class of 3 h duration respectively. FA concentration ranged from 0.11 to 1.07 mg/m3 in the cadaver storage room and 0.06-1.12 mg/m3 in the gross anatomy laboratory. In samples taken at 5 ft height at the breathing level, FA concentration ranged from 0.32 to 0.86 mg/m3. Conclusions: Most of the observed FA levels were found to be above the prescribed FA guideline values laid down by organizations such as OSHA, ACGIH, WHO, Japan Ministry of Health, Labor, and Welfare and, therefore, could be considered as harmful for students’ and teachers’ health. FA concentrations reported from a few medical facilities in other countries are comparable, implying that some uniform management and control strategies for FA could be contemplated to reduce risks of FA exposure to students and teachers which are discussed in this paper
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Distribution of ozone over urban Kolkata: observed vs UAM-V prediction(Journal of Ozone Science and Engineering)
(A. Talapatra, D. Majumdar and Anjali Srivastava,36(2),,181-190,Year : 2014)
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Vehicular pollution, emissions due to burning of fossil fuel from industries and nonpoint sources in Kolkata are major sources of air pollution characterized by oxides of Nitrogen (NOx) and volatile organic compounds (VOCs). These pollutants are also responsible for the secondary ozone formation based on their reactivities. In the present study ozone has been monitored hourly every month in residential, industrial, traffic intersections, and petrol pumps in the urban area of Kolkata along with eight hourly nonoxygenated VOCs,carbonyls and NOx. Urban Airshed Model (UAM-V) has been used to simulate ozone on January 14, 2008 in Kolkata’s urban Area. Results of predicted ground level ozone have been in agreement with observed ozone concentrations.
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Emission, speciation, and evaluation of impacts of non-methane volatile organic compounds from open dump site(Journal of the Air & Waste Management Association)
(D Majumdar, S Ray, S Chakraborty, PS Rao, AB Akolkar, M Chowdhury, A Srivastava. ,64 7,,834-845,Year : 2014)
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Surface emission from Dhapa, the only garbage disposal ground in Kolkata, is a matter of concern to the local environment and also fuels the issues of occupational and environmental health. Surface emission of the Dhapa landfill site was studied using a flux chamber measurement for nonmethane volatile organic compounds (NMVOCs). Eighteen noncarbonyl volatile organic compounds (VOCs) and 14 carbonyl VOCs, including suspected and known carcinogens, were found in appreciable concentrations. The concentrations of the target species in the flux chamber were found to be significantly higher for most of the species in summer than winter. Surface emission rate of landfill gas was estimated by using two different approaches to assess the applicability for an open landfill site. It was found that the emissions predicted using the model Land GEM version 3.02 is one to two orders less than the emission rate calculated from flux chamber measurement for the target species. Tropospheric ozone formation has a serious impact for NMVOC emission. The total ozone-forming potential (OFP) of the Dhapa dumping ground considering all target NMVOCs was estimated to be 4.9Eþ04 and 1.2Eþ05 g/day in winter and summer, respectively. Also, it was found that carbonyl VOCs play a more important role than noncarbonyl VOCs for tropospheric ozone formation. Cumulative cancer risk estimated for all the carcinogenic species was found to be 2792 for 1 million population, while the total noncancer hazard index (HI) was estimated to be 246 for the occupational exposure to different compounds from surface emission to the dump-site workers at Dhapa.
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